Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
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منابع مشابه
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury.
UNLABELLED Iron overload exacerbates various liver diseases. In hepatocytes, a portion of non-heme iron is sequestered in lysosomes and endosomes. The precise mechanisms by which lysosomal iron participates in hepatocellular injury remain uncertain. Here, our aim was to determine the role of intracellular movement of chelatable iron in oxidative stress-induced killing to cultured hepatocytes fr...
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BACKGROUND Sex-related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure. However, whether similar differences are seen in iron-overload cardiomyopathy is poorly understood. METHODS AND RESULTS Male and female wild-type and hemojuvelin-null mice we...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2008
ISSN: 0270-9139
DOI: 10.1002/hep.22498